Inhibition of Alanine Aminotransferase (alat) in Silico and in Vivo Promotes Mitochondrial Metabolism to Impair Malignant Growth*

INHIBITION OF ALANINE AMINOTRANSFERASE (ALAT) IN SILICO AND IN VIVO PROMOTES MITOCHONDRIAL METABOLISM TO IMPAIR MALIGNANT GROWTH* Gregor Beuster*, Kim Zarse*, Christoph Kaleta†, René Thierbach‡, Michael Kiehntopf§, Pablo Steinberg‡, Stefan Schuster†, Michael Ristow* װ 2 * Dept. of Human Nutrition, Inst. of Nutrition, University of Jena, Jena, D-07743, Germany, † Dept. of Bioinformatics, School of Biology and Pharmaceutics, University of Jena, Jena, D-07743, Germany, ‡ Dept. of Food Toxicology and Complementary Methods to Animal Testing, University of Veterinary Medicine Hannover, D-30173, Germany, § Inst. of Clinical Chemistry and Laboratory Medicine, University of Jena, Jena D-07743, Germany, װ Dept. of Clinical Nutrition, German Inst. of Human Nutrition Potsdam-Rehbrücke, Nuthetal, D-14558, Germany Running head: ALAT and cancer growth 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed: Dept. of Human Nutrition, Inst. of Nutrition, University of Jena, Jena, D-07743, Germany; Email: [email protected]